http://www.youtube.com/watch?v=ABm7DuBwJd8
I love the way he starts off by pretty much making fun of every TED conference and similar... then does his usual brilliant genius musical/humor/improv and whatnot...
no wonder Conan chose him (http://en.wikipedia.org/wiki/Reggie_Watts) to join along his "Legally Prohibited From Being Funny on Television" tour 8)