http://johnnyoptimism.blogspot.ca/search?updated-max=2010-06-11T13:12:00-05:00&max-results=6&reverse-paginate=true
I perused the archives (hence the link above) and seems like the author somehow has kept the sharp wit (and snark) going strong 3 years later.
The tone (and obviously the structure/design) kinda reminds me of GYWO (http://www.google.com/search?q=get+your+war+on). But also a slight dose of RM (http://www.redmeat.com/redmeat/). Enjoy (you sadists).
PS: what disease does Johnny have? nobody knows... (http://tvtropes.org/pmwiki/pmwiki.php/Webcomic/JohnnyOptimism)
Reminds me a bit of Zippy the Pinhead stock art / stamp comics (just with a thematic focus)